https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Inflammatory responses to acute pneumovirus infection in neonatal mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9716 Wed 11 Apr 2018 16:28:37 AEST ]]> Expression profiling of differentiating eosinophils in bone marrow cultures predicts functional links between microRNAs and their target mRNAs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16812 Wed 11 Apr 2018 12:55:19 AEST ]]> Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10124 Wed 11 Apr 2018 10:19:59 AEST ]]> Identification of MicroRNAs regulating the developmental pathways of bone marrow derived mast cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20638 Wed 11 Apr 2018 09:20:21 AEST ]]> Eosinophils: changing perspectives in health and disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18997 Tue 19 May 2020 06:14:58 AEST ]]> Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43341 Thu 15 Sep 2022 15:18:39 AEST ]]> Pulmonary eosinophils and their role in immunopathologic responses to formalin-inactivated pneumonia virus of mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7272 Sat 24 Mar 2018 08:33:52 AEDT ]]> Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13276 + T cell cytokine production was abrogated. The adoptive transfer of TLR7-sufficient, but not TLR7-deficient pDC to TLR7 gene-deleted mice recapitulated the antiviral responses observed in wild-type mice and promoted virus clearance. In summary, TLR7-mediated signaling by pDC is required for appropriate innate responses to acute pneumovirus infection. It is conceivable that as-yet–unidentified defects in the TLR7 signaling pathway may be associated with elevated levels of RSV-associated morbidity and mortality among otherwise healthy human infants.]]> Sat 24 Mar 2018 08:15:16 AEDT ]]> Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20418 Sat 24 Mar 2018 08:00:53 AEDT ]]> Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20751 Sat 24 Mar 2018 08:00:25 AEDT ]]> Eosinophils: biological properties and role in health and diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6617 Sat 24 Mar 2018 07:46:21 AEDT ]]> Targeting eosinophils in asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4795 Sat 24 Mar 2018 07:20:43 AEDT ]]> Modeling T<inf>H</inf>2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33088 H2 cells), their associated cytokines, and eosinophils in the regulation of hallmark features of allergic asthma. Notably, we consider the complexity of type-2 responses and studies that have explored integrated signaling among classical TH2 cytokines (IL-4, IL-5, and IL-13), which together with CCL11 (eotaxin-1) regulate critical aspects of eosinophil recruitment, allergic inflammation, and airway hyper-responsiveness (AHR). Among our most important findings, we have provided evidence that the initiation of TH2 responses is regulated by airway epithelial cell-derived factors, including TRAIL and MID1, which promote TH2 cell development via STAT6-dependent pathways. Further, we highlight studies demonstrating that microRNAs are key regulators of allergic inflammation and potential targets for anti-inflammatory therapy. On the background of TH2 inflammation, we have demonstrated that innate immune cells (notably, airway macrophages) play essential roles in the generation of steroid-resistant inflammation and AHR secondary to allergen- and pathogen-induced exacerbations. Our work clearly indicates that understanding the diversity and spatiotemporal role of the inflammatory response and its interactions with resident airway cells is critical to advancing knowledge on asthma pathogenesis and the development of new therapeutic approaches.]]> Fri 24 Aug 2018 16:27:29 AEST ]]> Eosinophils and COVID-19: diagnosis, prognosis, and vaccination strategies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40363 Fri 08 Jul 2022 14:24:38 AEST ]]>